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The choice of herb and secondary ingredient dictate which potion is made. Free players can instead obtain this potion through the Apothecary, requiring Red spider's eggs, a Limpwurt Root and 5 coins for each potion (produces 4 doses instead of 3).

Each potion has a minimum Herblore level required before it can be made, unless the assist system is used. This potion will wear off if the player wears something that is not goblin-related, if the player attacks something, or if the player approaches direct sunlight. Players receive partial experience (47.5, 52.5, and 60 xp for the 3-dose, e.g.) for each of the secondary ingredients. Combination potions provide effects of multiple regular high-level potions.

Both steps can be done in batches, which is when the player's inventory contains several of the required items, one may "make all" or "make x".

A finished potion will ordinarily give you a dose less than the vial gives potential to.

You can take the potions in noted form to a Decanter to increase or decrease the amount of doses per potion, provided you have enough vials if you decide to decrease the dose.