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Somewhere in Asia, the ancestral L3 lineages gave rise to haplogroups M and N.
The ancestral L3 lineages were then lost by genetic drift as they are infrequent outside Africa.
The hypothesis of Asia as the place of origin of macrohaplogroup M is supported by the following: According to this theory, haplogroups M and N arose from L3 in an East African population that had been isolated from other African populations.
Members of this population were involved in the out Africa migration and only carried M and N lineages.
These studies suggested that the migrations of haplogroups M and N occurred separately with haplogroup N heading northwards from East Africa to the Levant.